Search results for "la ss-b"

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The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of m…

1998

SUMMARY In a previous study it was shown that La/SSB contains four linear epitopes, p147–154, p291–302, p301–318 and p349–364. The aim of the present study was to investigate the value of the synthetic epitope analogues of the La/SSB autoantigen for the detection of antibodies to La/SSB, in comparison with recombinant La and fragments of this protein. A total of 122 sera with anti-La/SSB activity, from patients with primary Sjögren's syndrome (pSS) or systemic lupus erythematosus (SLE), were tested in various peptide-based assays. In addition, 62 sera from pSS or SLE patients with other autoantibody specificities and 95 sera from healthy individuals were used as controls. The autoantibody s…

systemic lupusantigenic peptidesMolecular Sequence DataImmunologyDot blotPeptideprimary sjogrens-syndromeBiologyAutoantigensSensitivity and SpecificityEpitopelaw.inventionsjogren's syndromeEpitopesAntigenlawmedicineantibodiesHumansImmunology and AllergyAmino Acid SequenceAutoantibodiesImmunoassaychemistry.chemical_classificationla/ssbcriteriaLinear epitopemedicine.diagnostic_testla ss-bAutoantibodyOriginal Articlessystemic lupus-erythematosusautoantigenRecombinant ProteinsSjogren's SyndromeclassificationRibonucleoproteinschemistryImmunoassayImmunologyRecombinant DNAdiagnostic valueb cell epitopesClinical and Experimental Immunology

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